Avastin stops tumor growth by blocking Vascular Endothelial Grow Factor receptor so the tumor fails to get a blood supply. In that case how can the drug interfere with blood pressure or cause side effects in the CNS?
Most likely what is occurring is functional retro-fraction and anatomical retrofraction. Functional retrofraction is the reduced permeability of the capillaries, while anatomical retrofraction is a reduced density of capillaries throughout the body. Capillary are continually formed in our bodies, not just at tumor sites and rebuilding and restorative growth are often needed.
Avastin can block these normal processes, and thus there is the same amount of blood, but a smaller area to contain it in.
CNS symptoms are not well understood at this time.
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Most likely what is occurring is functional retro-fraction and anatomical retrofraction. Functional retrofraction is the reduced permeability of the capillaries, while anatomical retrofraction is a reduced density of capillaries throughout the body. Capillary are continually formed in our bodies, not just at tumor sites and rebuilding and restorative growth are often needed.
Avastin can block these normal processes, and thus there is the same amount of blood, but a smaller area to contain it in.
CNS symptoms are not well understood at this time.
References :
Annals of Onocology + Doctor